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BRI has built a leading state-of-the-art infrastructure for the discovery and development of neuro-related therapeutics derived from Chinese medicine. Over the past few years, the Institute has successfully carried out the following programs with support from the Innovation and Technology Fund :
Development of Novel Subtype-specific Agonists for Melatonin Receptors (ITS/113/03)
The project capitalized on the Institute's discovery of novel compounds that exhibit agonistic activity at melatonin receptor subtypes. The lead compounds underwent detailed characterization, chemical modifications, and structure-activity-relationships determination.
Applied Genomics for Drug Discovery (ITS/226/01)
The project aimed to establish an applied genomic platform for the development of an expression profiling database to facilitate the discovery and development of neuro-related drug targets and small molecule therapeutics.
Establishing the SimBioDas "Artifical Gut" Technologies (UIM/036)
BRI researchers set up an ingredient profile for a selected Chinese medicine formula for liver cancer, using both conventional analytical methods and the SimBioDas "Artificial gut" technology developed by the Kinetana Hong Kong Herbal Pharmaceuticals Ltd.
Combinatorial Libraries Based on Compounds of Traditional Chinese Medicine (TCM) Origin (ITS/119/00)
The project focused on the establishment of state-of-the-art capabilities in combinatorial chemistry and developed valuable libraries of Chinese medicine-based combinatorial compounds.
Standardization and Certification of Chinese Medicine (ITS/173/00)
BRI was actively engaged in inter-institutional efforts to develop and prepare guidelines for the standardisation and certification of Chinese medicine in the form of monographs by surveying current documents and literature.
Development of Quality Index for Sanqi (Radix Notoginseng) from Wenshan, Yunnan (UIM/009)
Through this project, BRI and the New World Bioscience Co. Limited collaborated to develop a strategy using multiple approaches, namely DNA fingerprinting, chemical analysis and biological assays, for the assurance of efficacy and safety of Radix Notoginseng.
High-Throughput Drug Screening Center for TCM (AF/166/99)
The project involved the build-up of an integrated high-throughput drug screening capability to discover and identify Chinese medicine ingredients with promising clinical and commercial potentials.
Development of Innovative Genechip Technology (AF/150/99)
The project focused on the establishment of microarray fabrication expertise in order to produce microarray products for a number of applications such as drug discovery and genomics research.
Establishment of a BRI TCM Center (AF/178/97)
The Center was established with the goals to facilitate the advancement of Chinese medicine through multidisciplinary research and development activities and services, to foster the formation of strategic partnerships, and to provide the much needed high-technology services for the industry.

BRI is currently working together with other local institutions (CityU, CUHK, HKBU, HKU and PolyU) to explore the different aspects of two innovative herbal formulae, one for post-stroke rehabilitation and one for sleep-disorder, for their quality control, biological activities and clinical efficacy (ITF project ref: GHP/037/05)..

Besides these ITF funded initiatives, BRI scientists are also actively involved in a number of research activities for development of agents to help fight against age-related and neurodegenerative diseases.



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