The research team at BRI has established a strong publication track record through regular issue of scientific papers in high-impact journals. Listed below are some representative publications of the Institute since its inception:

  • Li Y, Song J, Tong Y, Chung SK, Wong YH. RGS19 upregulates Nm23-H1/2 metastasis suppressors by transcriptional activation via the cAMP/PKA/CREB pathway. Oncotarget. 2017 Jul 22;8(41):69945-69960.
  • Zuo H, Wong YH. Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ. BMC Cancer. 2015 Oct 24;15:775.
  • Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH. Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med. 2012 Jan;78(2):115-21.
  • Zhu J, Lee S, Ho MK, Hu Y, Pang H, Ip FC, Chin AC, Harley CB, Ip NY, Wong YH. In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab Pharmacokinet. 2010;25(5):477-86.
  • Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008 Sep 3;28(36):9002-12.
  • Shi L, Fu WY, Hung KW, Porchetta C, Hall C, Fu AK, Ip NY. Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16347-52.
  • Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007 Jan;10(1):67-76.
  • Trau D, Jiang J, Sucher NJ. Preservation of the biofunctionality of DNA and protein during microfabrication. Langmuir. 2006 Jan 31;22(3):877-81.
  • Fu AK, Ip FC, Fu WY, Cheung J, Wang JH, Yung WH, Ip NY. Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15224-9.
  • Fu AK, Fu WY, Ng AK, Chien WW, Ng YP, Wang JH, Ip NY. Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6728-33.
  • Zhao KJ, Dong TT, Cui XM, Tu PF, Tsim KW. Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains. Am J Chin Med. 2003;31(6):919-26.
  • Lai FP, Mody SM, Yung LY, Kam JY, Pang CS, Pang SF, Wong YH. Molecular determinants for the differential coupling of Galpha(16) to the melatonin MT1, MT2 and Xenopus Mel1c receptors. J Neurochem. 2002 Mar;80(5):736-45.
  • Li SP, Su ZR, Dong TT, Tsim KW. The fruiting body and its caterpillar host of Cordyceps sinensis show close resemblance in main constituents and anti-oxidation activity. Phytomedicine. 2002 May;9(4):319-24.
  • Chan SF, Sucher NJ. An NMDA receptor signaling complex with protein phosphatase 2A. J Neurosci. 2001 Oct 15;21(20):7985-92.
  • Miller-Martini DM, Chan RY, Ip NY, Sheu SJ, Wong YH. A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine. Phytother Res. 2001 Sep;15(6):487-92.
  • Fu AK, Fu WY, Cheung J, Tsim KW, Ip FC, Wang JH, Ip NY. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat Neurosci. 2001 Apr;4(4):374-81.
  • Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Trends Pharmacol Sci. 1999 May;20(5):191-6.
  • Cai ZH, Li P, Dong TT, Tsim KW. Molecular diversity of 5S-rRNA spacer domain in Fritillaria species revealed by PCR analysis. Planta Med. 1999 May;65(4):360-4.